Archive for the 'diseases' Category

Where Do New Viruses Come From?

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While the origin of the new Coronavirus is not yet known, we do know where new viruses normally come from. Hint: Darwin’s theory of evolution is full of clues!

In this animation you will get a crash course in virology. You’ll learn how viruses differ from other microbes, why most viruses can only infect one type of host organism, and how viruses evolve to infect new hosts.

For more information on evolution, visit https://www.statedclearly.com/

For more information on the idea that this virus may have come from a lab, see our article here: https://www.statedclearly.com/articles/did-the-new-coronavirus-came-from-a-lab/

For an excellent and accurate Q&A about the coronavirus, including things about how it is treated and how to stay safe, see this video by Dr. Ines Dawson. It’s long but don’t worry, in the video description she has a table of contents. Click the question you care about and it will jump right to that spot in the video! https://youtu.be/oA8XYSftmtQ

Further Reading:
Overview of how new viruses evolve during spillover events
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546865/

SARS coronavirus seems to have gone from bats to civets to people https://www.who.int/ith/diseases/sars/en/

RNA recombination as a source of genetic novelty in coronaviruses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC241489/pdf/jvirol00041-0423.pdf

How recombination and reassortment work:
https://www.nature.com/articles/nrmicro2614

Recombination in single stranded RNA viruses
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324781/

The evolution of SARS and a prediction that new coronaviruses will evolve in the future
https://jvi.asm.org/content/84/7/3134

How coronaviruses enter cells via binding and endocytosis: https://jvi.asm.org/content/92/3/e01933-17
https://www.nature.com/articles/cr200815

How we stopped the SARS coronavirus
https://www.cdc.gov/about/history/sars/timeline.htm

Pangolins as a potential intermediate host
https://www.nature.com/articles/d41586-020-00364-2

Corrections:
In the animation I call the virus COVID-19, but this is technically incorrect. COVID-19 is the name of the disease it causes. The virus itself is called SARS CoV 2. Thanks to YouTube user “Charles Starbuck” for pointing out the error.

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There are fossils of viruses, of sorts, preserved in the DNA of the hosts that they’ve infected. Including you. This molecular fossil trail can help us understand where viruses came from, how they evolved and it can even help us tackle the biggest question of all: Are viruses alive?

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References:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094976/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609113/
https://www.ncbi.nlm.nih.gov/pubmed/19270719/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096385/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758182/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190193/
https://hal.archives-ouvertes.fr/hal-00679842/document
http://bioinformatics.cvr.ac.uk/paleovirology/site/html/posts/2013-04-15_what_is_paleovirology.html
http://www.sciencemag.org/news/2017/04/giant-viruses-found-austrian-sewage-fuel-debate-over-potential-fourth-domain-life
https://www.khanacademy.org/test-prep/mcat/cells/viruses/a/are-viruses-dead-or-alive
https://serc.carleton.edu/microbelife/yellowstone/viruslive.html
https://www.nature.com/scitable/topicpage/the-origins-of-viruses-14398218#
https://www.nature.com/scitable/topicpage/discovery-of-the-giant-mimivirus-14402410
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976387/
https://www.nature.com/news/giant-viruses-open-pandora-s-box-1.13410
https://www.ncbi.nlm.nih.gov/pubmed/19561090
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946954/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906475/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179036/
https://www.theatlantic.com/science/archive/2018/05/a-7000-year-old-virus-sequenced-from-a-neolithic-mans-tooth/559862/
http://www.uniprot.org/uniprot/Q9P2P1
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1001191

Crohn's Disease: Pathophysiology, Symptoms, Risk factors, Diagnosis and Treatments, Animation.

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(USMLE topics) Crohn disease: pathophysiology, symptoms, causes, risk factors, complications, diagnosis and treatments. This video is available for instant download licensing here: https://www.alilamedicalmedia.com/-/galleries/narrated-videos-by-topics/digestive-diseases/-/medias/47f8d399-6671-487c-909c-2ed1eb5b6a77-crohn-s-disease-narrated-animation
Voice by: Ashley Fleming
©Alila Medical Media. All rights reserved.
Support us on Patreon and get early access to videos and free image downloads: patreon.com/AlilaMedicalMedia
All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Crohn’s disease is one of the 2 major forms of inflammatory bowel disease. Inflammation caused by Crohn’s disease may affect any parts of the gastrointestinal tract, but it most commonly involves the end of the small bowel, the ileum, and the beginning of the colon. The inflammation is not continuous, inflamed segments are usually interrupted by normal healthy tissues.
Most people experience recurrent flares, when the disease is active, followed by symptom-free periods of remission.
Symptoms may differ depending on the parts of the digestive tract that are affected. Most common signs include diarrhea, abdominal pain and tenderness, loss of appetite, weight loss, fatigue and fever. Blood in stools occurs when the colon is involved; nausea and vomiting are usually the signs that the stomach or the first part of the small intestine is affected. About one third of patients present with perianal disease, including abscess, fistulas and ulcers. The disease also often manifests outside the intestine, especially in the joints, skin, and eyes.
Inflammation in Crohn’s disease extends to the entire thickness of the intestinal wall. Deep lesions in the mucosa often alternate with areas of mucosal swelling, creating a characteristic cobblestoned appearance. Extensive inflammation may cause thickening of the bowel wall and hypertrophy of the mesenteric fat that wraps around the intestine (creeping fat). Intestinal wall thickening, together with scar formation, may block the flow of digestive content, leading to bowel obstruction. Ulcers can extend through the bowel wall and form tunnels, called fistulas, which may connect to other loops of the intestine, to abdominal organs, muscles and even skin. A fistula may become infected and form abscesses, which can be life-threatening if not treated. In the long-term, Crohn’s disease may increase risks for colon cancers.
The disease has a major peak of onset between the age of 20 and 30, and a smaller peak later in life. White individuals, people with family history, and smokers are at higher risks.
The exact mechanism of Crohn’s disease is not fully understood, but it likely involves both genetic and environmental factors. Multiple genes are identified, most of which act in the immune system, or in maintaining the gastrointestinal epithelial barrier. This barrier separates the gut content from the underlying immune system, preventing the body from reacting to dietary antigens and resident bacteria of the gut. A crack in the barrier may increase the chance that the immune system overreacts to non-pathogenic antigens from the gut content.
Involvement of environmental factors is evidenced by higher disease incidence in developed countries, especially urban areas.
Diagnosis is made based on a combination of tests and imaging procedures.
Treatments start with dietary management to maintain good nutrition but avoid foods that may exacerbate symptoms. Some patients may benefit from nutrition therapy, a special diet given via a feeding tube or injected into a vein. The therapy provides nutrition while allowing the bowel to rest, reducing inflammation.
A number of medications can be prescribed depending on disease severity and the patient’s response to different drugs. These may include: antidiarrheals, anti-inflammatories, antibiotics, corticosteroids, immunomodulators and biologics.
Abscesses and fistulas are drained and treated with antibiotics.
Nearly half of patients require at least one surgery to manage recurrent intestinal obstructions or complicated fistulas or abscesses. Surgical removal of the diseased parts of the bowel may improve symptoms temporarily, but is not a cure, because the disease is likely to recur, usually near the reconnected tissue.
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Crohn’s disease is difficult to diagnose, because the symptoms overlap with other diseases. Physicals, x-rays, colonoscopies and biopsies aid in diagnosis.
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Autosomal Recessive Inheritance – Genetics

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This video describes autosomal recessive inheritance where healthy carrier parents have a 25% chance of having a child affected with a particular genetic condition.

Examples of recessive conditions include cystic fibrosis, spinal muscular atrophy, Tay-Sachs disease and many other rare conditions

http://www.kaleidoscope.org.au/site/hunter-genetics
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What is Sickle Cell Disease?

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What is sickle cell disease? Watch this video to learn more about this lifelong blood disorder and test your knowledge with a quiz at the end.

What is sickle cell anemia? Sickle cell anemia is an autosomal recessive genetic condition where the beta-globin protein subunit of hemoglobin is misshapen, which ultimately leads to a sickle-shaped red blood cell, which is prematurely destroyed and can get stuck in small blood vessels.

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Medical disclaimer: Knowledge Diffusion Inc (DBA Osmosis) does not provide medical advice. Osmosis and the content available on Osmosis’s properties (Osmosis.org, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.

Canine Dementia: everything you need to know about senility in dogs

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Canine Dementia: everything you need to know about senility in dogs

Senility in dogs, canine dementia or canine cognitive dysfunction are different names for the same disease. Our pet dogs are living longer than ever and as a result senility is also becoming a common problem.

Unfortunately though it is only recognized and treated in a small proportion of those dogs actually suffering from dementia.

Join me as I go through the causes, signs and symptoms, treatment, prognosis and life expectancy of canine cognitive dysfunction. Taking action at an early stage has the potential to make all the difference in your senior dogs quality of life.

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Disclaimers: all opinions are my own, sponsors are acknowledged. Links in description are typically affiliate links that let you help support the channel at no extra cost.
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The information provided on the Our Pets Health YouTube channel is not a substitute for the examination, assessment and advice given in person by a suitably qualified veterinary surgeon. The information is provided for educational and entertainment purposes only and does not constitute specific vet advice for any individual cat, dog or other animal of any species.
for more information head over to OurPetsHealth.com
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Canine distemper is a virus that affects the skin, brain, eyes, respiratory, and intestinal organs of dogs. Though it is a highly infectious disease, it is entirely preventable by vaccination. Dogs of all age are at risk, though it mostly affects puppies under the age of six months. There are ways to recognize the symptoms so you can get your dog treated.

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Image: Recognize-Distemper-Symptoms-in-Dogs-Step-1-Version-2 | By:Wikivisual0

– /images/1/15/Recognize-Distemper-Symptoms-in-Dogs-Step-1-Version-2.jpg – licensed by Creative Commons – cc-by-sa-nc-3.0-self —- creativecommons.org/licenses/by-nc-sa/3.0/us/ -Last updated:15:32, 11 February 2016

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Image: Recognize-Distemper-Symptoms-in-Dogs-Step-2-Version-2 | By:Wikivisual0

– /images/8/82/Recognize-Distemper-Symptoms-in-Dogs-Step-2-Version-2.jpg – licensed by Creative Commons – cc-by-sa-nc-3.0-self —- creativecommons.org/licenses/by-nc-sa/3.0/us/ -Last updated:15:32, 11 February 2016

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Image: Recognize-Distemper-Symptoms-in-Dogs-Step-3-Version-2 | By:Wikivisual0

– /images/7/73/Recognize-Distemper-Symptoms-in-Dogs-Step-3-Version-2.jpg – licensed by Creative Commons – cc-by-sa-nc-3.0-self —- creativecommons.org/licenses/by-nc-sa/3.0/us/ -Last updated:15:32, 11 February 2016

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Image: Recognize-Distemper-Symptoms-in-Dogs-Step-4 | By:Wikivisual0

– /images/6/65/Recognize-Distemper-Symptoms-in-Dogs-Step-4.jpg – licensed by Creative Commons – cc-by-sa-nc-3.0-self —- creativecommons.org/licenses/by-nc-sa/3.0/us/ -Last updated:15:32, 11 February 2016

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Image: Recognize-Distemper-Symptoms-in-Dogs-Step-5 | By:Wikivisual0

– /images/f/f4/Recognize-Distemper-Symptoms-in-Dogs-Step-5.jpg – licensed by Creative Commons – cc-by-sa-nc-3.0-self —- creativecommons.org/licenses/by-nc-sa/3.0/us/ -Last updated:15:32, 11 February 2016

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Image: Recognize-Distemper-Symptoms-in-Dogs-Step-6 | By:Wikivisual0

– /images/8/87/Recognize-Distemper-Symptoms-in-Dogs-Step-6.jpg – licensed by Creative Commons – cc-by-sa-nc-3.0-self —- creativecommons.org/licenses/by-nc-sa/3.0/us/ -Last updated:15:32, 11 February 2016

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Image: Recognize-Distemper-Symptoms-in-Dogs-Step-7 | By:Wikivisual0

– /images/e/e0/Recognize-Distemper-Symptoms-in-Dogs-Step-7.jpg – licensed by Creative Commons – cc-by-sa-nc-3.0-self —- creativecommons.org/licenses/by-nc-sa/3.0/us/ -Last updated:15:32, 11 February 2016

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Image: Recognize-Distemper-Symptoms-in-Dogs-Step-8 | By:Wikivisual0

– /images/b/be/Recognize-Distemper-Symptoms-in-Dogs-Step-8.jpg – licensed by Creative Commons – cc-by-sa-nc-3.0-self —- creativecommons.org/licenses/by-nc-sa/3.0/us/ -Last updated:15:32, 11 February 2016

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Website———————————wikihow.com——————-

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Expert Reviewer–//wikihow.com/Special:ArticleReviewers?name=pippaelliott,mrcvspippaelliott,mrcvs —- Pippa Elliott, MRCVS

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————————-References———————
—pets.webmd.com/dogs/canine-distemper

—Diagnosis, therapy, and prevention of common infectious disease in the dog. Greene. Vet Q 1

—Small Animal Internal Medicine. Nelson & Couto. Publisher: Mosby

—1800petmeds.com/education/canine-distemper-symptoms-dogs-49.htm

—avma.org/public/PetCare/Pages/Canine-Distemper.aspx

—petmd.com/dog/conditions/respiratory/c_dg_canine_distemper

—1800petmeds.com/education/canine-distemper-symptoms-dogs-49.htm

—pets.webmd.com/dogs/canine-distemper

—petmd.com/dog/conditions/respiratory/c_dg_canine_distemper

—avma.org/public/PetCare/Pages/Canine-Distemper.aspx

—htt
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Buerger's Disease (Thromboangiitis Obliterans) | Vasculitis Mnemonic

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Buerger’s Disease, also known as Thromboangiitis Obliterans, is a medium-vessel vasculitis that is strongly associated with smoking; it is commonly seen in males younger than 40-years-old. Clinically, Buerger’s disease presents with intermittent claudication, which refers to pain caused by lack of blood flow (especially during exercise). When this affects the fingers, patients can develop Raynaud phenomenon, which refers to the fingers’ change in color from white to blue to red when placed under cold water. When the finger ischemia is even more severe, gangrene and autoamputation of the digits can occur (hence why “obliterans” is in the name). Buerger’s disease patient may also develop superficial nodular phlebitis, which refers to pain and inflammation along veins. pathology reveals a segmental, thrombosing vasculitis with vein and nerve involvement. Smoking cessation is not curative, but it has been shown to slow progression and severity of Buerger’s disease.

Learn about Buerger disease and other #medicalschool topics with Pixorize’s #USMLE Step 1 mnemonics. Part of our Metabolic Disorders playlist for the USMLE Step 1 exam.

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Buerger disease (also known as the thromboangiitis obliterans) is a type of vasculitis that affects small and medium blood vessels and has been linked strongly to smoking. Buerger disease is characterised by poor blood flow through blood vessels due to inflammation and blood clotting. Symptoms typically include pain (claudication), increased sensitivity to cold, diminished pulses, and cyanosis. Gangrene is often a complication which may require amputation of the affected area. Learn how health care professionals diagnose Buerger disease using ultrasound and angiography. Created by Ian Mannarino.

Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/rn-cardiovascular-diseases/rn-vasculitis/v/wegeners-granulomatosis-and-microscopic-polyangiitis?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn

Missed the previous lesson? https://www.khanacademy.org/test-prep/nclex-rn/rn-cardiovascular-diseases/rn-vasculitis/v/kawasaki-disease-diagnosis-and-treatment?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn

NCLEX-RN on Khan Academy: A collection of questions from content covered on the NCLEX-RN. These questions are available under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States License (available at http://creativecommons.org/licenses/by-nc-sa/3.0/us/).

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What is Batten Disease

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Sara Mole, PhD at the University College of London describes Batten disease and the difficulty in educating clinicians about this extremely rare condition.

We talked with Dr Mole at the 15th International Conference on Neuronal Ceroid Lipfuscinosis (Batten Disease) held in Boston, MA; October 5-8, 2016.
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Hepatitis C: CDC Viral Hepatitis Serology Training

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Hepatitis C: CDC Viral Hepatitis Serology Training

This training video covers the different serologic tests and serological diagnosis for acute and chronic Hepatitis C virus (HCV) infection and helps the learner understand the meanings of serologic markers and interpret serologic test results.

Comments on this video are allowed in accordance with our comment policy: http://www.cdc.gov/SocialMedia/Tools/CommentPolicy.html

This video can also be viewed at

“Brain on Fire” Condition Explained: What is Anti-NMDA Receptor Encephalitis?

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“Brain on Fire” Condition Explained: What is Anti-NMDA Receptor Encephalitis?

Awareness about anti-NMDA receptor encephalitis increased earlier this year when Netflix aired Brain on Fire, a movie that tells the real-life story of one young woman’s experience with the condition.

“Anti-NMDA receptor encephalitis is a condition in which the immune system essentially attacks the brain,” said Felipe De Los Rios, M.D., medical director of the stroke program at Baptist Health Neuroscience Center. “It’s not very common, but is one of the most common causes of autoimmune encephalitis.”

See the full story here: https://baptisthealth.net/baptist-health-news/brain-on-fire-condition-explained-whats-anti-nmda-receptor-encephalitis-video/

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[Transcript]

[Graphic: Baptist Health South Florida logo, “Brain on Fire” Condition Explained: What is Anti-NMDA Receptor Encephalitis?, gentle music]

[Felipe De Los Rios, M.D., Medical Director of the Stroke Program at Baptist Health Neuroscience Center] Normally, we have this set of mechanisms to protect us against germs and viruses and other harms that might be there in the environment.

But, sometimes your own body starts recognizing as something strange or foreign, your own, parts of your own cells.

[Picture: Brain scan, Graphic: NMDA, N-Methyl-D-aspartic] In this condition in particular, it attacks a receptor called NMDA in your brain.

People who have this condition can start initially by having subtle memory problems, usually is what we called anterograde amnesia. So, it’s things with day-to-day task, appointments, things like that. [Picture: Brain scan] But, it quickly progresses gets worse and worse, to the point that it doesn’t let you function.

The treatment is a combination of immunotherapies. It’s not yet one standardized treatment. [Video: Doctor walking, looking at brain scan] There’s not one way to treat this condition. What they search, is to dampen down your immune response so, that your own body is not attacking that receptor.

It’s not a very common condition like, for example, the flu or something like that. But, it is one of the most common causes of encephalitis, that we can diagnose and now treat.

[Picture: Brain scan] It is very important to have, an early contact with specialists and subspecialists that are familiar with this condition and that have that technology to treat it.

[Video: Front of Miami Cardiac & Vascular Institute, Control room] So, here at Baptist Health, we have the neurologists, the specialists, that are required to diagnose this condition, and we have all the tools to treat it as well.

[Graphic: Connect BaptistHealthSF, Facebook, Twitter, Youtube, Instagram, Pinterest, Snapchat, Gentle music]
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Vitamin C Deficiency (Scurvy) Symptoms (ex. bad teeth, fatigue), Why symptoms happen & who gets them

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Vitamin C Deficiency (Scurvy) Symptoms (ex. bad teeth, fatigue), Why symptoms happen & who gets them

Lesson on Vitamin C (Ascorbic acid) deficiency (Scurvy) signs and symptoms, the pathophysiology of vitamin C deficiency, why symptoms occurs, who gets these symptoms, and an in-depth overview of the condition known as scurvy. Vitamin C is an essential vitamin that is required for several metabolic pathways including collagen synthesis, and catecholamine synthesis among others. In the event of reduced dietary intake of vitamin C, the condition of scurvy can occur which leads to symptoms involving the teeth, skin, hair and can even cause depression, fatigue and weakness. Diagnosis includes laboratory investigations and treatment depends on whether the patient is a child or an adult.

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Check out some of my other lessons.

Medical Terminology – The Basics – Lesson 1:

Fatty Acid Synthesis Pathway:

Wnt/B Catenin Signaling Pathway:

Upper vs. Lower Motor Neuron Lesions:

Lesson on the Purine Synthesis and Salvage Pathway:

Gastrulation | Formation of Germ Layers:

Introductory lesson on Autophagy (Macroautophagy):

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Rheumatology Playlist

Endocrinology Playlist

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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*Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.*

I am always looking for ways to improve my lessons! Please don’t hesitate to leave me feedback and comments – all of your feedback is greatly appreciated! 🙂 And please don’t hesitate to send me any messages if you need any help – I will try my best to be here to help you guys 🙂

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